The Journal
Explore our latest articles, insights, and stories from the PEPAX team.
hydrogen water for hangoverAlcohol metabolism floods the body with acetaldehyde and reactive oxygen species — the chemistry behind the hangover. Molecular hydrogen...
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magnesium and heart palpitationsPalpitations and skipped beats are among the most common signs of subclinical magnesium deficiency. Magnesium stabilizes cardiac membrane potential...
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NMN and autophagyAutophagy is the cell's recycling system, and it declines sharply with age. NAD+-dependent sirtuins (especially SIRT1) directly activate the autophagy...
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NAD+ forms explainedNAD exists in oxidized (NAD+) and reduced (NADH) forms, each serving distinct metabolic roles. NAD+ levels — not NADH —...
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senolyticsQuercetin and dasatinib combination has the most human senolytic evidence, showing reduced senescent cell burden in diabetic kidney disease. NMN supports autophagy-related...
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oxidative stress biomarkers8-OHdG, F2-isoprostanes, and MDA are the most validated oxidative stress biomarkers in human research. This article explains what each measures,...
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anti-aging supplements evidenceRapamycin, NMN, metformin, senolytic combinations, and caloric restriction mimetics have all entered human trials. This evidence-based review summarizes the current...
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hydrogen water and hearingCochlear hair cells are especially vulnerable to oxidative stress from noise exposure and ototoxic drugs. Animal studies show hydrogen-rich...
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hydrogen water for seniorsAging is characterized by a progressive imbalance between ROS production and antioxidant defenses. Studies in older adults show hydrogen...
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