The Journal

Explore our latest articles, insights, and stories from the PEPAX team.

supplement stacking safety | PEPAX Supplements
JUN 03, 2026 Supplement Stacking Safety: Interactions to Know When Combining NMN, Magnesium, and H2

supplement stacking safetyMost longevity supplements have favorable interaction profiles, but specific combinations — NMN with blood thinners, magnesium with certain antibiotics, high-dose...

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hydrogen water and cancer | PEPAX Supplements
JUN 03, 2026 Hydrogen Water in Cancer Care: What Early Research Shows and What It Doesn't

hydrogen water and cancerJapanese oncology trials suggest hydrogen inhalation may reduce chemo side effects without diminishing treatment efficacy. This article reviews the...

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magnesium and depression | PEPAX Supplements
JUN 03, 2026 Magnesium and Depression: Clinical Evidence and the Serotonin Connection

magnesium and depressionMagnesium modulates NMDA receptor activity and influences serotonin synthesis — two key pathways in depressive disorders. A 2017 open-label RCT...

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NMN and exercise capacity | PEPAX Supplements
JUN 03, 2026 NMN and Exercise Capacity: How NAD+ Affects Endurance and Aerobic Performance

NMN and exercise capacityA 2022 trial found NMN improved walking endurance and muscle oxygen utilization in older adults. This article reviews what...

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hydrogen water cardiovascular | PEPAX Supplements
JUN 03, 2026 Hydrogen Water and Heart Health: Blood Pressure and Cardiovascular Risk Markers

hydrogen water cardiovascularTwo clinical trials have tested hydrogen water in patients with metabolic syndrome and found reductions in LDL oxidation and triglycerides....

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magnesium and Alzheimer's | PEPAX Supplements
JUN 03, 2026 Magnesium and Memory: Alzheimer's Risk Reduction and Neuroprotection Research

magnesium and Alzheimer'sEpidemiological data links higher dietary magnesium intake with lower dementia risk. Animal models show magnesium modulates NMDA receptor activity and...

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NMN and neuropathy | PEPAX Supplements
JUN 03, 2026 NMN and Neuropathy: NAD+ and Peripheral Nerve Function Research

NMN and neuropathyPeripheral neurons require substantial NAD+ for axon maintenance and repair. Animal models show NMN may delay chemotherapy-induced neuropathy and age-related...

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hydrogen water and fertility | PEPAX Supplements
JUN 03, 2026 Hydrogen Water and Male Fertility: Sperm Motility, DNA Integrity, and Oxidative Protection

hydrogen water and fertilityOxidative stress is responsible for up to 40% of male infertility cases. Animal studies show hydrogen water improves sperm...

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magnesium calcium ratio | PEPAX Supplements
JUN 03, 2026 The Magnesium-Calcium Ratio: Why Balance Matters More Than Either Alone

magnesium calcium ratioCalcium and magnesium compete for absorption and have opposing effects on muscle contraction and nerve signaling. A 2:1 calcium-to-magnesium ratio...

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